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KMID : 0043319990220020202
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Archives of Pharmacal Research
1999 Volume.22 No. 2 p.202 ~ p.207
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Synthesis and Biological Studies of Catechol Ether Type Derivatives as Potential Phosphodiesterase (PDE) IV Inhibitors
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Rhee Chung K.
Kim Jong-Hoon
Suh Byung-Chul
Xiang Myung-Xik
Youn Yong-Sik
Bang Won-Young
Kim Eui-Kyung
Shin Jae-Kyu
Lee Youn-Ha
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Abstract
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New series of catechol ether type derivatives 5, 6 have been synthesized and applied to biological tests. Even though it is ap preliminary data, some of our target molecules show the promising result against PDE IV inhibition. SAR and biological studies with studies with synthetic compounds will be discussed in detail.
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KEYWORD
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Phosphodiesterase (PDE), Anti-asthma therapy, Structure-activity relationship (SAR), Catechol ether type PDE IV inhibitors
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